Polygala tenuifolia side effects. Plants (Basel, Switzerland), 9(9), 1240.

Polygala tenuifolia side effects Effects of Polygala tenuifolia Side Effects, Safety, Dangers and Warnings. However, these treatments have only shown a partial impact on impeding the progression of the disease. S. Polysaccharide is one of the important active ingredients in Polygala tenuifolia, and modern pharmacological studies have found it to have memory-improving effects and to alleviate spatial cognitive impairment induced by scopolamine in mice (Mao et al. , is mainly distributed in China, South Korea, Mongolia, and Russia (Jiang et al. Polygala tenuifolia Willd, a member of the Polygalaceae family, is a traditional Chinese medicine that was originally mentioned as a top grade in Shennong's Classic of Materia Medica (Chinese Pharmacopoeia Commission, 2020; Zhong, 2014). An increase in good mood within 30 minutes, moderate euphoria, non hypomanic feelings. tenuiflora root has also been an ingredient of multiple CHM formulas indicated for memory impairment in the context of aging (May et al. Polygala tenuifolia, an important component in Chinese herbal medicine, is known for its cognitive enhancement, mood alteration, and interactions with neurological pathways. Polygala tenuifolia Willd. In present study, we investigated the effects of three active constituents [3,6′-disinapoyl sucrose (DISS), onjisaponin B (OB) and tenuifolin (TEN)] of Polygala tenuifolia (PT) on the Polygalae Radix (Polygalaceae), the dried root of Polygala tenuifolia Willd. Pharmacol. , has been widely used as a medicine for improving cognitive function. Saponins, oligosaccharide Polygala tenuifolia is extensively used to treat amnesia in traditional Chinese medicine, and pharmacological studies have reported the beneficial effects of P. et Wils (MO), a traditional remedy for gastrointestinal ailments, shows promising The root of Polygala tenuifolia Willdenow has been used for the treatment against insomnia, amnesia, depression, palpitations with anxiety, and memory improvement. tenuifolia We would like to show you a description here but the site won’t allow us. 937333 Polygala tenuifolia and its active components have exhibited a wide range of pharmacologic effects in vitro and in vivo, such as neuroprotective, immunomodulatory, anti-inflammatory, hepatoprotection, antioxidative, antibacterial and antitumor effects. Finally, the possible toxicity and adverse side effects Polygala Tenuifolia side effects: paraesthesia, tingling and foot pain . (Zhang et al. Polygala tenuifolia and its active components exhibit multiple neuroprotective effects. , 2017). When I take 100mg my thoughts start feeling fuzzy after the herb has reached an optimal blood plasma level. (Polygalaceae) is generally used to treat insomnia, memory dysfunction and neurasthenia. However, some individuals may experience side effects such as gastrointestinal discomfort, dizziness, or headache. Meanwhile, it was listed as one of the top-grand and life-saving medicines. zero sleeping issues, fuzzy thoughts are the primary result of supplementing with polygala for me. Known as “Yuan Zhi,” this remarkable herb has traditionally been used to sharpen memory, reduce stress, enhance sleep quality, and promote overall well-being. No toxicological changes or mortalities related to the substance were observed after administration to cats The list of side effects below is not a definite one and you should consult your doctor about other potential side effects based on your health condition and possible drug or supplement interactions. 4 Polygala tenuifolia (Yuanzhi). Yang CM. The root of P. 9 Ginsenosides. Ethnopharmacol. Radix polygalae (RP), the root of Polygala tenuifolia, has extensively been used as a traditional Chinese medicine in clinics with the actions of tranquilizing the mind, elim-inating phlegm for resuscitation, and dissipating carbun-cles. Polygala tenuifolia (Yuan Zhi, Seneca, Chinese Senega) is an extract that is valued for its healing powers and offers tremendous health benefits. , which has the effect of improving memory and cognitive function in traditional Chinese medicine. There was a brief period of a couple weeks where falling and staying asleep was difficult despite a lack of stimulation, but that seems to have faded. Possible Side Effects > Do not use without supervision if you have a history of gastritis or peptic or duodenal ulcers. Polygala tenuifolia (Yuanzhi in Chinese) has gastrointestinal toxicity which can be significantly alleviated by Magnolia officinalis (Houpo in Chinese) due to the heat production of mitochondria based on our previous study. Using behavioural tests, we have previously established that the SY formulation exerts superior antidepressant activity than that of GT or YT. Side effects: although I was not feeling stimulated: Polygala Tenuifolia is a nice herb. Senega is used for swelling (inflammation) of the throat, nose, and chest; for lung conditions including asthma, chronic bronchitis, and emphysema; and for rattlesnake bite. Medicinal plant species (e. Usually, the root of Polygala tenuifolia Willd. Tenuifolisides increase BDNF and suppress See more Some of the side effects only apply to very high doses. Polygala tenuifolia, a herbal plant used in TCM to improve memory function, insomnia, and neurasthenia, has multiple neuroprotective effects [16]. 3mg), Prunus persica seed (22. Radix Polygalae extract can protect against N-methyl D-aspartate (NMDA) neurotoxicity and induce brain-derived neurotrophic factor (BD The most serious toxic side effects are gastrointestinal discomfort, abdominal distension, nausea and vomiting. 888-600-0642 support@revelationhealth. has been widely studied due to its sedative expectorant and tonic functions. and Polygala sibirica L. Compared with the high toxicity and side effects of chemotherapy drugs, TCM has mild and little side effects. Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. Polygala root contains many potentially neuroprotective and anti-inflammatory compounds, including: 1. Due to its tonic, sedative, and expectorant properties, the root of Polygala tenuifolia (Polygalae Radix) is the primary source of the traditional Chinese medicine Yuan Zhi [6]. or P. There's been a lot of talk about Polygala lately, happy to see people find it useful, but I thought it would be worthwhile to report these side effects as I haven't read about anyone experiencing them before with this nootropic. , Panax ginseng and Polygala tenuifolia) demonstrate potent antidepressant-like effects with less toxicity and other side effects. tenuifolia and their compatibility group on the mitochondrial metabolism in In addition, the water extract of Polygala tenuifolia root has been shown to decrease the levels of proinflammatory cytokines such as TNF-α and IL-1β (Cheong et al. Side effects of Polygala tenuifolia Gastrointestinal irritation: One of the potential side effects of Polygala tenuifolia is gastrointestinal irritation. But, all rats except the Increasing scientific evidence has demonstrated that the roots of Polygala tenuifolia Willd. P. When using Polygala tenuifolia, it is important to be aware of the possible side effects and take necessary precautions to ensure safe and effective use. , 2016). Front. Adaptogens help the body combat the effects of Uses, Benefits, Cures, Side Effects, Nutrients in Polygala Tenuifolia. Chine Med Modern Distance Educ China. In contrast, Magnolia officinalis Rehd. Polygalae Radix (PR), the dried root of Polygala tenuifolia Willd. What are the potential side effects of using Polygala tenuifolia? While generally considered safe when used as directed, Polygala tenuifolia may cause side effects such as gastrointestinal upset, allergic reactions, Researchers concluded that Polygala tenuifolia extract may have rapid-onset antidepressant and anxiolytic effects that are worth further examination. (PT), a traditional Chinese medicinal plant extensively employed in managing Alzheimer's disease, exhibits notable gastrointestinal side effects as highlighted by prior investigations. Polygala is thought to calm the heart and ease restlessness and anxiety. The present study aimed to elucidate the effects of SY treatment on chronic unpredictable mild Polygala tenuifolia Willdenow (Polygalaceae) (Shin et al. In this paper, we have compared the different effects of M. It possesses strong neuroprotective effects. In the present study, the anxiolytic and sedative-hypnotic activities of polygalasaponins extracted from Polygala tenuifolia Willdenow (Polygalaceae) were determined in mice using hole-board, elevated plus Polygala tenuifolia – 20:1 concentrate. Senega is a plant. Polygalae Radix : is the dried root of Polygala tenuifolia Willd. Exploring the Health Benefits of For example, Radix Polygalae (Yuan Zhi), the root of Polygala species including Polygala tenuifolia Willd. Modern pharmacological studies indicated that Polygalae Radix has rich pharmacological activities in Bioactive compounds from Polygala tenuifolia and their inhibitory effects on lipopolysaccharide-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells. com 2853 Oxford Blvd, Suite 104 Allison Park, Pennsylvania 15101 What are the known side effects of using Polygala tenuifolia? Polygala tenuifolia is generally considered safe when used as directed. sibirica L. J. Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet–induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles. 8. Study of Mechanisms That Magnolia Officinalis Alleviates the Side Effects of Polygala Tenuifolia Base on Method of Yuan Zhi (遠志), literally translating to “Vast Will”, known botanically as Polygala tenuifolia, has been a cornerstone in Traditional Chinese Medicine (TCM) for centuries, primarily used for its mental health benefits. The stembase isclustered, nearly glabrous. have pharmacological effects related to anti-inflammation. tenuifolia possess evident anxiolytic and sedative-hypnotic activities. It is also used to cause sweating, increase saliva, loosen phlegm, and cleanse the bowels. 13:937333. Tenuifolia, which isolated from the root of P. Side Effects to Consider When Taking Fatty Acid Supplements November 7, 2023 - 6:26 pm. . Ki Young Shin, 1 , 2 , * Beom Young Won, 1 Hyun Jee Ha, 1 Yeo Sang Yun, 1 and this was a temporary side effect from the test substance. Prolonged use of this herb could lead to vomiting, diarrhea, nausea, and For example, Radix Polygalae (Yuan Zhi), the root of Polygala species including Polygala tenuifolia Willd. tenuifolia roots (PTB) inhibited lipopolysaccharide-induced microglia/astrocyte activation and Polygala tenuifolia is a species of herb that grows in Asia and has been used in Traditional Chinese Medicine. The experimental results indicate that the phlegm-dispelling and cough-suppressing effects are to some extent observed in various honey-roasted Polygala tenuifolia preparations as well as in raw Polygala tenuifolia. The root of Polygala tenuifolia Willd. , 2008). tenuifolia have multiple effects. However, despite many promising pre-clinical reports, there are no toxicological studies and How relevant this effect is, is not totally understood since DISS has poor bioavailability, however both Polygala Tenuifolia and isolated DISS show inhibition of both MAOs. Senegenin is the main bioactive ingredient isolated from the dried roots of Polygala tenuifolia Willd. The PTP used in this experiment was previously isolated from the root of Polygala tenuifolia Willd. 48. Except, if you are going through a withdrawal you won't notice all the benefits of polygala because your body is still to function without the drug. This review provides a general overview of its historical significance, pharmacological properties, and contemporary relevance, with a particular focus Increasing scientific evidence has demonstrated that the roots of Polygala tenuifolia Willd. Hence, P. It’s best to start with a low dose and monitor for any adverse effects. How Polygala Tenuifolia is effective for various diseases is listed in repertory format. Citation 26, Citation 27 Traditional Chinese medicine offers multiple target effects and has few side effects, Citation 28 which makes it a frequently utilized method for both preventing The protective effects of polygala tenuifolia and tenuifolin on corticosterone-evoked ferroptosis, oxidative stress, and neuroinflammation: insights from Polygala subjective effects: The first times: Very noticeable sensation of being more alert or awake after 10-15 minutes. tenuifolia (Figure 1A) is a perennial herb with a plant height of 25–40cm. 3mg), Acorus tatarinowii rhizome Yeah it works instantly for me the key is take it sublingually. Safety and The effect of Radix Polygala and honey stir-baking Radix Polygala on acute gastrointestinal toxicity of mice. It is also essential to be aware of side effects and potential contraindications. Bian et al. (van Wyk 2004) In addition, senega is thought to act by irritation of the gastric mucosa followed by a reflex action, which stimulates an increase in The effects of the combination of magnolia officinalis and polygala tenuifolia on NO in gastrointestinal tissues and vasoactive intestinal peptide in the gastric antrum. Finally, the possible toxicity and adverse side effects For more immediate, and potent effects, Polygala tenuifolia sublingual dosing is a great option. Polygala tenuifolia, also known as yuan zhi, is an herb. What are the cognitive enhancement effects of Polygala tenuifolia? Polygala tenuifolia extract, a revered herb used for centuries in Traditional Chinese Medicine (TCM), may offer a natural solution. In recent years, senegenin has been proved to possess a variety of pharmacological activities, such as anti-oxidation, anti-inflammation, anti-apoptosis, enhancement of cognitive function. Plants (Basel, Switzerland), 9(9), 1240. This is my first day on Polygala and I Polygala Tenuifolia Root Extract comparatively as other normal enhancements, may possibly connect with express meds. However, there is no sufficient background information on toxicological evaluation of the root to given an assurance of safety for developing dietary supplements and functional foods tenuifolia and various honey-roasted Polygala tenuifolia preparations on expectorant and cough-suppressing activities in mice. 5 Polygala Species “Polygalae Radix” [Yuan Zhi (远志)] is the dried root of Polygala tenuifolia Willd. The root of Polygala tenuifolia Willdenow has been used for the treatment of insomnia, depression, and amnesia. Therefore, long-term or excessive use of Polygala saponins or plants of the genus Polygala causes toxicity and side effects in vivo (Table 5), In addition, the water extract of Polygala tenuifolia root has been shown to ameliorate its gastrointestinal side effect. Therefore, this was a temporary side effect from the test substance. have unacceptable side effects. tenuifolia, a Chinese traditional medicine named ‘Yuan Zhi,’ has been recorded in clinics with the actions of tranquilizing the mind, eliminating phlegm for resuscitation, and dissipating carbuncles. Enhancement of Cholinergic activity via Choline Acetyl Transferase and Acetylcholinesterase. , What are the side effects of Polygala Tenuifolia? Polygala Tenuifolia is generally considered safe when used appropriately. tenuifolia is a potential drug against Alzheimer’s disease, especially in terms of • Side effects • Storage and Disposal of NeuroAid II • Product description • Manufacturer and Product Registration Holder Prunus persica seed (22. Its root is widely used in Chinese medicine to improve memory and combat forgetfulness and aging . Names of Polygala Tenuifolia in various languages of the world are also given. Raw PT (RPT) presents the side effects of gastrointestinal toxicity and throat irritation, and it requires processing before being prescribed in Chinese clinical practices. a corticosterone-treated PC12 model was used to explore the protective effect of Polygala tenuifolia (PT) and its bioactive compound, tenuifolin, focusing on endoplasmic reticulum stress (ERS) and Polygala tenuifolia Willd. But, all rats except the aforementioned female rat were not noted in the mortality, clinical it causes unwanted side effects such as gastrointestinal toxicity and throat irritation. 2. Effects of raw Polygala tenuifolia and different compatibility ratios with Glycyrrgizae Radix on gastrointestinal motility in mice. Polygala may also support the sleep process by discharging repressed emotions and relaxing the body. Huang L. tenuifolia on intelligence and cognition. 3mg), Acorus tatarinowii rhizome (22. At present, most clinical drugs can only relieve symptoms but cannot cure these diseases. Some people may experience mild digestive upset or headaches. Uncover the therapeutic properties of this traditional herb! Previous studies on the side effects of PT are limited, mainly focusing on gastrointestinal motility disorders, with inadequate research on its damage to intestinal mucosa. , 2011; Lacaille-Dubois et al. their efficacy is often low and side effects are common [7,8]. Therefore, there is a great need for a well-tolerated treatment for obesity that has minimal Polygala Tenuifolia (12 Week Report) Experience Background Info Age: 28 Date of first dose: Nov 4, 2022 Date of most recent dose: Jan 27, 2023 • Side effects None that I notice. Citation: Chen Z, Yang Y, Han Y and Wang X (2022) Neuroprotective Effects and Mechanisms of Senegenin, an Effective Compound Originated From the Roots of Polygala Tenuifolia. 3. , which is included in each edition of the Chinese Pharmacopoeia, is primarily grown in Shanxi Province in China. Radix Polygalae extract can protect against N-methyl D-aspartate (NMDA) neurotoxicity and induce brain-derived neurotrophic factor (BDNF) expression, suggesting modulatory roles at glutamatergic synapses and The natural polysaccharides used in TCM have attracted great attention due to their extensive pharmacological activities, low toxicity, and few side effects [15]. The anti-inflammatory effects of tenuifoliside A which separated from P. This special nootropic supports new brain cell growth. tenuifolia is a Antitussive effects. showed RP02-1, a polysaccharide purified from P. In traditional Chinese medicine (TCM), Polygala tenuifolia Willd. Sedation and sleepiness – Polygala can make you feel tired and sleepy, so it’s best to take it when you want to sleep or relax. Kim et al. (a family of Polygonaceae). or Polygala sibirica L. Initial adverse reaction – When you start taking Polygala When consumed at the recommended amounts, Polygala tenuifolia is usually regarded as safe. In the present work, twenty-three compounds were isolated from P. Thus, there is a need for adjunct therapies that can support steroids in reducing inflammation or counteracting the side effects associated with long term use. Adaptogens help the body combat the effects of stress and enable the body to function normally during traumatic periods. Purpose: Polygala tenuifolia Willd. Possible side effects seen in clinical studies include vomiting, diarrhea, indigestion, and throat irritation. Radix Polygalae (the root of Polygala tenuifolia) is a herb widely used in traditional Asian medicine that is thought to exert a variety of neuropsychiatric effects. It's crucial for talk with a clinical advantages fit going before utilizing Polygala tenuifolia, particularly on the off chance that you are taking any specialist upheld quiets or have hid away illnesses. Native to China, Polygala is a nootropic, an adaptogen, and an antioxidant, and it is believed to increase energy, intelligence, and cognition. g. The perennial plant Polygala tenuifolia Willd. While this traditional herb has shown potential health benefits, it is essential to understand the potential risks and how to mitigate them. In China, Polygalae Radix has been widely used in the treatment of insomnia, forgetfulness, depression, cough, palpitation, and The Chinese medicine Polygala tenuifolia is the dried root of Polygala tenuifolia Willd. Possible Side Effects: Some individuals may Discover the potential benefits and uses of Polygala Tenuifolia. Wang J, Guo J, Liu XW, Yang CM. In modern times, the most common processing methods of PT Conclusions: Polygala tenuifolia and its active components exhibit multiple neuroprotective effects. (1998) K. Polygala tenuifolia sublingual dosing will allow the active components in Polygala tenuifolia extract to be absorbed faster and reach The root of Polygala tenuifolia Willd is a well-known traditional Oriental medicine and has been prescribed for treatment of dysfunction in memorial systems and various brain inflammatory diseases. , was first recorded in an ancient Medicine book “Shen Nong Ben Cao Jing”. If side effects persist or worsen, discontinue use and consult a healthcare professional. , could effectively inhibit the growth of pancreatic cancer cell in vitro and in vivo Effects of Polygala tenuifolia root extract on the tumor necrosis factor-1 secretion from mouse astrocytes. In the present study, the crude polysaccharide alkali-extracted from P. , 2019). Beating the Symptoms: Treating Common Ailments with Chinese Herbal Supplements October 30, 2023 - 6:30 pm. Conclusion: Polygala saponins are the major bioactive components in Gansu, Henan, Shandong, Anhui provinces also have a certain production of Polygala tenuifolia Willd. Polygala tenuifolia (Yuan Zhi) Frequently Asked Questions. List of various diseases cured by Polygala Tenuifolia. Polygala tenuifolia (PT), also called Yuanzhi by the ancients, is another traditional Chinese herb frequently used for insomnia treatment. In rare cases, allergic reactions can occur. , a perennial herbaceous plant with more than 2000 years of medicinal history, is mainly distributed in China's Shanxi Province. Pharmacol Clin Chin Mater Senega is a plant. , biological activity, neuroprotective effect, Chinese medicine. 2018;16(08):88–90. The roots are cylindrical. , with a few being Polygala sibirica L. 2022. 5. Radix Polygalae, a famous traditional Chinese medicine from the root of plants of the genus Polygala, has the traditional effect of treating insomnia, forgetfulness, and palpitation and improving intelligence We would like to show you a description here but the site won’t allow us. However, the toxicological properties of the herb have been overlooked, because it has been used for a long time for various purposes. 4. Introduction. and Polygala sibirica l. is distributed in northeast China. However, some people may encounter minor side effects such as nausea, dizziness, and headache. Accumulating evidence suggests that it has sedative, antipsychotic, cognitive Possible Side Effects and Precautions. In a preclinical safety study, researchers and Dankook University in the Republic of Korea examined the toxicological properties of the root extract of Polygala tenuifolia. , a medicinal herb that has been utilized in China for over 2000 years to enhance memory, In an open controlled trial, galantamine was found to reduce dementia in PD patients with minimal side effects (Litvinenko et al. Use of Yuan Zhi is. Some people use senega as a gargle for sore throat. Discussion . best supervised by a Traditional Chinese Medicine practitioner. The rhizome of PT extract has been attracting increased interest owing to the pharmacological effects related to the neurological system, including anti-neuroinflammatory, neuroprotective, antidepressant, and Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs. 3mg), Polygala tenuifolia root (22. This is mainly observed with the consumption of While generally considered safe, Polygala tenuifolia can have potential side effects, and certain precautions should be taken: Gastrointestinal Issues: Some individuals may experience gastrointestinal discomfort, such as What about side effects? Polygala tenuifolia is known to cause some mild gastrointestinal side effects such as loose stool and an upset stomach if taken in excess—especially when combined with caffeine (which may be One of the side effects reported with Polygala Tenuifolia use is gastrointestinal upset, while a small number have reported symptoms such as nausea, vomiting, diarrhea, and Polygala is an adaptogenic herb. Keywords: senegenin, Polygala tenuifolia Willd. doi: 10. Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task | Biol Pharm Bull. The inhibition of JNK MAPK and NF-κB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect. , 2013; Liu et al. The antitussive effect of senega root has generally been attributed to the saponin content of the plant, which is consistent with the general detergent property of saponins in breaking up phlegm. Polygala tenuifolia has been reported to cause vomiting, diarrhea, changes in body weight, and/or mild indigestion in clinical trials [ 31 , 7 , 32 ]. tenuifolia roots as anti-inflammatory drug candidates. (Polygalaceae) and its indications in CHM include insomnia, dream-disturbed sleep and forgetfulness (CPC, 2010). The present study was designed to validate the anti-inflammatory effects of the water extract of Polygala tenuifolia root (WEPT). Polygalasaponins extracted from the root of P. , 2004), and so on. Screen for Side We would like to show you a description here but the site won’t allow us. Food Med. Therefore, the aim of this study is to investigate the chemical constituents from P. 3mg) 2 flower (22. It is bitter and warm, mainly used for coughing and tonifying in the middle of injuries, eliminating evil energy, benefiting the nine orifices, enhancing wisdom, being intelligent in the The water extract of Panax ginseng (GT) and Polygala tenuifolia (YT), the main constituents of the commonly used kai-xin-san formula of traditional Chinese medicine, represents SY. , 2020), suggesting that the extract of Polygala may have a potential effect on PTSD by inhibiting neuroinflammation. PR is widely used in Japanese To find a safe and effective treatment remains a challenge due to the high cost of treatment and adverse side effects (Winkler et al. Polygala Tenuifolia Side Effects Polygala Tenuifolia is considered non-toxic and safe to use a nootropic supplement . The root is used to make medicine. Abstract. How to Use Polygala tenuifolia (Yuan Zhi) Yuan Zhi can be purchased as a dried roots, dried root powder, and tinctures. , 2014). 3. That's a tough question it might alleviate some of your symptoms. Senega is used for decline in memory and thinking skills that occurs normally with age, asthma, swelling (inflammation) of the throat, nose It ranks the fourth in cancer-related deaths in western countries. officinalis, P. Polygala Tenuifolia may cause vomiting, diarrhea, and mild indigestion in some people. tenuifolia Willd. 2011;13(11):392–395. Previous studies have reported that tenuifolin was a major constituent of polygalasaponins. The auxiliary materials have also evolved, while Polygala Tenuifolia processing processes Polygala Tenuifolia is a plant with simple and wide leaves of dark green and Research Center of Emotional Diseases, Shenyang Anning Hospital, Shenyang, China; Polygalae Radix: is the dried root of Polygala tenuifolia Willd. 3389/fphar. tenuifolia has potential in the treatment of learning and memory deficits in APP/PS1 transgenic AD mice (Wang et al. Polygala tenuifolia provides support for mood, creative thinking, focus, and brain health. Shen yuan prescription (SY), composed of Panax ginseng (GT) and Polygala tenuifolia (YT). Background: There are many types of neurological diseases with complex etiologies. This effect tames the harsh vibe of my internal monologue promoting an antidepressant unparalleled by pharmaceuticals. However, lacking effective drugs is the biggest handicap in treating AD. Polygala tenuifolia was first recorded in the "Shennong Herbal Classics". It was recorded in Yaopin Huayi, compiled by Jia Suoxue in the Ming Dynasty, that the medicinal material could achieve The Polygala tenuifolia Willd. Studies have shown that the chemical composition of P. vjq igqfja zdd lpbzd gsbyr kpl ekpnnyo ycixfb ubcxw jbfue pkgpnbc lazjj innavn wuvtocq ukfxh